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Chromogranin A Deficiency Attenuates Tauopathy by Altering Epinephrine–Alpha-Adrenergic Receptor Signaling

2024-08-09

Abstract excerpt

<title>Abstract</title> <p>Metabolic disorders such as insulin resistance and hypertension are potential risk factors for aging and neurodegenerative diseases. These conditions are reversed in Chromogranin A knockout (CgA-KO) mice. This study investigates the role of CgA in Alzheimer’s disease (AD) and corticobasal degeneration (CBD). CgA ablation in tauopathy mice (hTau) (CgA-KO/hTau) exhibited reduced tau aggre...

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Literature Corpus work
c7890361-fba0-552f-8ec7-e5e6de2729be
DOI
10.21203/rs.3.rs-4797912/v1
Open publication

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Chromogranin A Deficiency Attenuates Tauopathy by Altering Epinephrine–Alpha-Adrenergic Receptor SignalingDOI 10.21203/rs.3.rs-4797912/v1
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