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Article

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease.

Neuropharmacology - 1 Jun 2017

Zhu Haihao, Xue Xiehua, Wang Erming, Wallack Max, Na Hana, Hooker Jacob M, Kowall Neil, Tao Qiushan, Stein Thor D, Wolozin Benjamin, Qiu Wei Qiao

Abstract excerpt

Amylin is an important gut-brain axis hormone. Since amylin and amyloid-β peptide (Aβ) share similar β sheet secondary structure despite not having the same primary sequences, we hypothesized that the accumulation of Aβ in the brains of subjects with Alzheimer's disease (AD) might compete with amylin for binding to the amylin receptor (AmR). If true, adding exogenous amylin type peptides would compete with Aβ and...

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Identifiers

PMID: 28363773
DOI: 10.1016/j.neuropharm.2017.03.030
PMCID: PMC6511375

Genes

CDK5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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