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Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine–Alpha-Adrenergic Receptor Signaling

2024-06-12

Abstract excerpt

<h4>Summary</h4> Our previous studies have indicated that insulin resistance, hyperglycemia, and hypertension in aged wild-type (WT) mice can be reversed in mice lacking chromogranin-A (CgA-KO mice). These health conditions are associated with a higher risk of Alzheimer’s disease (AD). CgA, a neuroendocrine secretory protein has been detected in protein aggregates in the brains of AD patients. Here, we determined...

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Literature Corpus work
f6435b88-a351-50ef-96ab-952e2ec8d313
DOI
10.1101/2024.06.11.598548
Open publication

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Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine–Alpha-Adrenergic Receptor SignalingDOI 10.1101/2024.06.11.598548
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