The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation

Abstract excerpt

Accumulation of amyloid β (Aβ) peptides and hyperphosphorylated tau proteins in the hippocampus triggers cognitive memory decline in Alzheimer’s disease (AD). The incidence and mortality of sporadic AD were tightly associated with diabetes and hyperlipidemia, while the exact linked molecular is uncertain. Here, we reported that serum Kallistatin concentrations were meaningfully higher in AD patients, with a higher...

Topics

Open a Topic to create a Post that cites this publication.

• Amyloid beta-Protein Precursor
• Amyloid Precursor Protein Secretases
• Aspartic Acid Endopeptidases
• Cholesterol
• Dementia
• Diet and metabolism studies
• Dyslipidemias
• Genetic Predisposition to Disease

Identifiers and source

Literature Corpus work

e2d1afc0-349f-503f-8780-817f2339e503

DOI

10.1101/2024.05.20.594915