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Article

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

12 Jun 2007

Abstract excerpt

Alzheimer's disease (AD) is an age-dependent neurodegenerative disease that causes progressive cognitive impairment. The initiation and progression of AD has been linked to cholesterol metabolism and inflammation, processes that can be modulated by liver x receptors (LXRs). We show here that endogenous LXR signaling impacts the development of AD-related pathology. Genetic loss of either Lxralpha or Lxrbeta in...

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PMID: 17563384
DOI: 10.1073/pnas.0701096104

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