Article

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

2020-01-29

Abstract excerpt

<h4>Summary</h4> We recently used CRISPRi/a-based chemical-genetic screens and targeted cell biological, biochemical, and structural assays to determine that rigosertib, an anti-cancer agent in phase III clinical trials, kills cancer cells by destabilizing microtubules. In a recent manuscript, Reddy and co-workers suggest that this microtubule-destabilizing activity of rigosertib is mediated not by rigosertib its...

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Literature Corpus work: aeb348ea-794e-58f1-8b65-7c767ab0f838
DOI: 10.1101/2020.01.28.923235

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