Article

Diverse microtubule-destabilizing drugs induce equivalent molecular pathway responses in endothelial cells

2025-01-24

Abstract excerpt

Drugs that modulate microtubule (MT) dynamics are well-characterized at the molecular level, yet the mechanisms linking these molecular effects to their distinct clinical outcomes remain unclear. Several MT-destabilizing drugs, including vinblastine, combretastatin A4, and plinabulin, are widely used, or are under evaluation for cancer treatment. Although all three depolymerize MTs, they do so through distinct bio...

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Literature Corpus work: 3fe1cfa4-d4b2-5958-b177-115e120c0aee
DOI: 10.1101/2025.01.22.632572

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