Microtubule inhibitors: Differentiating tubulin-inhibiting agents based on mechanisms of action, clinical activity, and resistance

Abstract excerpt

Microtubules are important cellular targets for anticancer therapy because of their key role in mitosis. Microtubule inhibitors (MTI) such as taxanes, vinca alkaloids, and epothilones stabilize or destabilize microtubules, thereby suppressing microtubule dynamics required for proper mitotic function, effectively blocking cell cycle progression and resulting in apoptosis. In spite of their antitumor activity,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 14-3-3 protein interactions
• Share to Cancer Treatment and Pharmacology
• Share to Microtubule and mitosis dynamics