Article

Mechanism of action of rigosertib does not involve tubulin binding

2019-12-12

Abstract excerpt

<h4>SUMMARY</h4> Rigosertib is a novel benzyl styryl sulfone that inhibits the growth of a wide variety of human tumor cells in vitro and in vivo and is currently in Phase III clinical trials. We recently provided structural and biochemical evidence to show that rigosertib acts as a RAS-mimetic by binding to Ras Binding Domains (RBDs) of the RAF and PI3K family proteins and disrupts their binding to RAS. In a r...

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Identifiers and source

Literature Corpus work: 30c7dd3d-555a-5d2a-a4ed-54f4d6b5cc98
DOI: 10.1101/2019.12.12.874719

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