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Article

Microtubule-Targeting Drugs: More than Antimitotics

5 Mar 2019

Abstract excerpt

Nature has yielded numerous compounds that bind to tubulin/microtubules and disrupt microtubule function. Even with the advent of targeted therapies for cancer, natural products and their derivatives that target microtubules are some of the most effective drugs used in the treatment of solid tumors and hematological malignancies. For decades, these drugs were thought to work solely through their ability to...

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PMID: 30835122
DOI: 10.1021/acs.jnatprod.9b00105

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