Article
A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent.
Molecular cell - 2 Jul 2020
Baker Stacey J, Cosenza Stephen C, Athuluri-Divakar Saikrishna, Reddy M V Ramana, Vasquez-Del Carpio Rodrigo, Jain Rinku, Aggarwal Aneel K, Reddy E Premkumar
Abstract excerpt
Rigosertib is a styryl benzyl sulfone that inhibits growth of tumor cells and acts as a RAS mimetic by binding to Ras binding domains of RAS effectors. A recent study attributed rigosertib's mechanism of action to microtubule binding. In that study, rigosertib was obtained from a commercial vendor. We compared the purity of clinical-grade and commercially sourced rigosertib and found that commercially sourced...
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