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Functional genetics reveals modulators of anti-microtubule drug sensitivity

2024-03-13

Abstract excerpt

Microtubules play essential roles in diverse cellular processes and are important pharmacological targets for treating human disease. Here, we sought to identify cellular factors that modulate the sensitivity of cells to anti-microtubule drugs. We conducted a genome-wide CRISPR/Cas9-based functional genetics screen in human cells treated with the microtubule-destabilizing drug nocodazole or the microtubule-stabili...

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Literature Corpus work
32eebf7a-60e8-5d5d-84c6-662d2c0a759f
DOI
10.1101/2024.03.12.584469
Open publication

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Functional genetics reveals modulators of anti-microtubule drug sensitivityDOI 10.1101/2024.03.12.584469
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