Article

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

2020-09-11

Abstract excerpt

Microtubule, composed of αβ-tubulin heterodimers, remains as one of the most popular anticancer targets for decades. To date, anti-microtubule drugs are mainly functionally divided into microtubule-destabilizing and microtubule-stabilizing agents while microtubule- or tubulin-degradation agents are rarely reported. Six known binding sites on tubulin dimer are identified with five sites on β-tubulin and only one si...

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Literature Corpus work: 8edeb144-4640-5496-b5f7-3d783fefbd1a
DOI: 10.1101/2020.09.11.293563

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