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Repositioning Microtubule Stabilizing Drugs for Brain Disorders

8 Aug 2018

Abstract excerpt

Microtubule stabilizing agents are among the most clinically useful chemotherapeutic drugs. Mostly, they act to stabilize microtubules and inhibit cell division. While not without side effects, new generations of these compounds display improved pharmacokinetic properties and brain penetrance. Neurological disorders are intrinsically associated with microtubule defects, and efforts to reposition...

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PMID: 30135644
DOI: 10.3389/fncel.2018.00226

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