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Article

STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer.

Cancer research communications - 1 Oct 2022

Athans Sarah, Krishnan Nithya, Ramakrishnan Swathi, Cortes Gomez Eduardo, Lage-Vickers Sofía, Rak Monika, Kazmierczak Zara, Ohm Joyce, Attwood Kristopher, Wang Jianmin, Woloszynska Anna

Abstract excerpt

STAG2 (Stromal Antigen 2), in healthy somatic cells, functions in sister chromatid cohesion, DNA damage repair, and genome organization, but its role in muscle invasive bladder cancer (MIBC) remains unknown. Here, using whole-exome and targeted sequencing (n=119 bladder cancer clinical samples), we found several STAG2 mutations in MIBC that correlate with loss of protein expression. The analysis of a bladder...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36275363
DOI: 10.1158/2767-9764.crc-22-0155
PMCID: PMC9583756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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