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Article

The role of STAG2 in bladder cancer.

Pharmacological research - 1 May 2018

Aquila Lanni, Ohm Joyce, Woloszynska-Read Anna

Abstract excerpt

Stromal Antigen 2 (STAG2) is one of four components of the cohesin complex and predominantly functions in sister chromatid cohesion and segregation. STAG2 is the most frequently mutated cohesin subunit and was recently identified as a gene that is commonly altered in bladder cancer. The significance of these mutations remains controversial. Some studies associate loss of STAG2 expression with low stage and low...

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Share to Aneuploidy
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Neoplastic

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Source

Identifiers

PMID: 29501732
DOI: 10.1016/j.phrs.2018.02.025

Genes

STAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

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Research trail→

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The role of STAG2 in bladder cancer.PMID 29501732Read ↗

Recurrent inactivation of STAG2 in bladder cancer is not associated with aneuploidy.Semantic proximity Read ↗

STAG2 expression is associated with adverse survival outcomes and regulates cell phenotype in muscle-invasive bladder cancer.Semantic proximity Read ↗

STAG2 loss-of-function affects short-range genomic contacts and modulates the basal-luminal transcriptional program of bladder cancer cellsSemantic proximity Read ↗

STAG2 loss-of-function affects short-range genomic contacts and modulates urothelial differentiation in bladder cancer cellsSemantic proximity Read ↗

Frequent inactivating mutations of STAG2 in bladder cancer are associated with low tumour grade and stage and inversely related to chromosomal copy number changes.Semantic proximity Read ↗

STAG2 regulates polycomb and differentiation in urothelial precursors and bladder cancer.Semantic proximity Read ↗

Mutational and expressional analyses of STAG2 gene in solid cancers.Semantic proximity Read ↗

Mutational inactivation of STAG2 causes aneuploidy in human cancer.Semantic proximity Read ↗

STAG2 Coupled With p53 Alteration Has a Significant Impact on Bladder Cancer Recurrence and ProgressionSemantic proximity Read ↗

Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.Semantic proximity Read ↗

STAG2 Regulates Homologous Recombination Repair and Sensitivity to ATM InhibitionSemantic proximity Read ↗

Hardwired synthetic lethality within the cohesin complex in human cancer cellsSemantic proximity Read ↗

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