Article

Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational Scanning

2021-11-24

Abstract excerpt

<h4>ABSTRACT</h4> Stabilizing antigenic proteins as vaccine immunogens or diagnostic reagents is a stringent case of protein engineering and design as the exterior surface must maintain recognition by receptor(s) and antigen—specific antibodies at multiple distinct epitopes. This is a challenge, as stability-enhancing mutations must be focused on the protein core, whereas successful computational stabilization al...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae98864b-2901-52e1-8019-625bd9ab5680
DOI: 10.1101/2021.11.22.469552

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Stabilization of the SARS-CoV-2 Receptor Binding Domain by Protein Core Redesign and Deep Mutational ScanningDOI 10.1101/2021.11.22.469552Read

Stabilization of the SARS-CoV-2 receptor binding domain by protein core redesign and deep mutational scanning.Semantic proximity Read

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based designSemantic proximity Read

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design.Semantic proximity Read

Prefusion spike protein stabilization through computational mutagenesisSemantic proximity Read

Prefusion spike protein stabilization through computational mutagenesis.Semantic proximity Read

A general computational design strategy for stabilizing viral class I fusion proteinsSemantic proximity Read

Automated selection of stabilizing mutations in designed and natural proteins.Semantic proximity Read

Enhanced stability of the SARS CoV-2 spike glycoprotein trimer following modification of an alanine cavity in the protein coreSemantic proximity Read

Simulation-driven design of stabilized SARS-CoV-2 spike S2 immunogensSemantic proximity Read

DisruPPI: structure-based computational redesign algorithm for protein binding disruption.Semantic proximity Read

Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational designSemantic proximity Read

Stability and expression of SARS-CoV-2 spike-protein mutations.Semantic proximity Read