Article

A general computational design strategy for stabilizing viral class I fusion proteins

2023-03-17

Abstract excerpt

Many pathogenic viruses, including influenza virus, Ebola virus, coronaviruses, and Pneumoviruses, rely on class I fusion proteins to fuse viral and cellular membranes. To drive the fusion process, class I fusion proteins undergo an irreversible conformational change from a metastable prefusion state to an energetically more favorable and stable postfusion state. An increasing amount of evidence exists highlightin...

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Literature Corpus work: 3aa6cf62-eab8-5b09-b405-bc87ef5062ca
DOI: 10.1101/2023.03.16.532924

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