Article

Stabilization of the SARS-CoV-2 Spike receptor-binding domain using deep mutational scanning and structure-based design

2021-05-16

Abstract excerpt

<h4>ABSTRACT</h4> The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need for highly effective vaccine candidates that are thermostable and amenable to large-scale manufacturing. Nanoparticle immunogens presenting the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein (S) in repetitive arrays are being advanced as second-generation vaccine candidates, as they feature robust ma...

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Literature Corpus work: 6c9332bd-c7a1-5736-b87c-3a88d41a3981
DOI: 10.1101/2021.05.15.444222

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