Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design.

doi:10.3389/fimmu.2021.710263

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Article

Stabilization of the SARS-CoV-2 Spike Receptor-Binding Domain Using Deep Mutational Scanning and Structure-Based Design.

Frontiers in immunology - 1 Jan 2021

Ellis Daniel, Brunette Natalie, Crawford Katharine H D, Walls Alexandra C, Pham Minh N, Chen Chengbo, Herpoldt Karla-Luise, Fiala Brooke, Murphy Michael, Pettie Deleah, Kraft John C, Malone Keara D, Navarro Mary Jane, Ogohara Cassandra, Kepl Elizabeth, Ravichandran Rashmi, Sydeman Claire, Ahlrichs Maggie, Johnson Max, Blackstone Alyssa, Carter Lauren, Starr Tyler N, Greaney Allison J, Lee Kelly K, Veesler David, Bloom Jesse D, King Neil P

Abstract excerpt

The unprecedented global demand for SARS-CoV-2 vaccines has demonstrated the need for highly effective vaccine candidates that are thermostable and amenable to large-scale manufacturing. Nanoparticle immunogens presenting the receptor-binding domain (RBD) of the SARS-CoV-2 Spike protein (S) in repetitive arrays are being advanced as second-generation vaccine candidates, as they feature robust manufacturing...

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Identifiers

PMID: 34267764
DOI: 10.3389/fimmu.2021.710263
PMCID: PMC8276696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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