Article

Insights into the stability of a therapeutic antibody Fab fragment by molecular dynamics and its stabilization by computational design

2019-05-20

Abstract excerpt

Successful development of protein therapeutics depends critically on achieving stability under a range of conditions, while retaining their specific mode of action. Gaining a deeper understanding of the drivers of instability across different stress conditions, will potentially enable the engineering of protein scaffolds that are inherently manufacturable and stable. Here, we compared the structural robustness of...

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Literature Corpus work: 841af947-e2d5-5318-ad71-81d6934ec4cf
DOI: 10.1101/644369

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