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Article

DisruPPI: structure-based computational redesign algorithm for protein binding disruption.

Bioinformatics (Oxford, England) - 1 Jul 2018

Choi Yoonjoo, Furlon Jacob M, Amos Ryan B, Griswold Karl E, Bailey-Kellogg Chris

Abstract excerpt

Motivation: Disruption of protein-protein interactions can mitigate antibody recognition of therapeutic proteins, yield monomeric forms of oligomeric proteins, and elucidate signaling mechanisms, among other applications. While designing affinity-enhancing mutations remains generally quite challenging, both statistically and physically based computational methods can precisely identify affinity-reducing...

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Identifiers

PMID: 29949961
DOI: 10.1093/bioinformatics/bty274
PMCID: PMC6022686

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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