Article

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance

2024-11-13

Abstract excerpt

Global health and food supply are endangered by an increasing frequency of antifungal resistance in pathogenic fungi. Wild-type fission yeast, Schizosaccharomyces pombe , can gain resistance to insults such as caffeine and antifungal compounds through reversible epimutations. Resistant epimutants exhibit histone H3K9 methylation-dependent heterochromatin islands at various chromosomal locations, reducing expressi...

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Literature Corpus work: ae7e9793-e1a2-510f-82e3-2bf7e8a89823
DOI: 10.1101/2024.11.13.623381

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