Article

Chromosome-scale CRISPR screening reveals secretory pathway genes as drivers of aneuploidy-mediated antifungal tolerance

2026-07-24

Abstract excerpt

The gain or loss of chromosomes in eukaryotes often drives aberrant phenotypes by altering the expression levels of hundreds or thousands of genes. In the case of beneficial aneuploidies, the genetic basis of fitness improvement has rarely been pinpointed, and identifying the causal genes remains a major challenge in engineering biology. The leading cause of human fungal infections, Candida albicans , frequently...

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Literature Corpus work: e679a862-526c-5a8d-8fb4-6da4913262d0
DOI: 10.64898/2026.07.23.740334

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