Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance.

doi:10.1038/s44318-025-00649-0

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Article

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance.

The EMBO journal - 1 Jan 2026

Fellas Andreas, Pidoux Alison L, Tong Pin, Hewes Harriet H, Wallace Emma C, Allshire Robin C

Abstract excerpt

Antifungal resistance in pathogenic fungi endanger global health and food supply. Wild-type fission yeast, Schizosaccharomyces pombe, can gain resistance to insults including caffeine and antifungal compounds through reversible epimutations. Resistant epimutants exhibit ectopic histone-H3K9 methylation-dependent heterochromatin islands, repressing underlying genes. Two genes whose heterochromatin island-induced...

Topics

Drug Resistance, Fungal
Schizosaccharomyces
Heterochromatin
Mitochondria
Schizosaccharomyces pombe Proteins
Antifungal Agents
Gene Expression Regulation, Fungal
Mutation
Basic-Leucine Zipper Transcription Factors
Mitochondrial Proteins

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Identifiers

PMID: 41326690
DOI: 10.1038/s44318-025-00649-0
PMCID: PMC12811382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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