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Article

Epigenetic gene silencing by heterochromatin primes fungal resistance.

Nature - 1 Sept 2020

Torres-Garcia Sito, Yaseen Imtiyaz, Shukla Manu, Audergon Pauline N C B, White Sharon A, Pidoux Alison L, Allshire Robin C

Abstract excerpt

Heterochromatin that depends on histone H3 lysine 9 methylation (H3K9me) renders embedded genes transcriptionally silent1-3. In the fission yeast Schizosaccharomyces pombe, H3K9me heterochromatin can be transmitted through cell division provided the counteracting demethylase Epe1 is absent4,5. Heterochromatin heritability might allow wild-type cells under certain conditions to acquire epimutations, which could...

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Identifiers

PMID: 32908306
DOI: 10.1038/s41586-020-2706-x
PMCID: PMC7116710

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