Article

Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistance

2021-12-20

Abstract excerpt

Epe1 histone demethylase restricts H3K9-methylation-dependent heterochromatin, preventing it from spreading over, and silencing, gene-containing regions in fission yeast. External stress induces an adaptive response allowing heterochromatin island formation that confers resistance on surviving wild-type lineages. Here we investigate the mechanism by which Epe1 is regulated in response to stress. Exposure to caffei...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bda4c2b8-3c0a-58be-8513-bc9b0f6bcb7e
DOI: 10.1101/2021.12.20.473483

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteasome-dependent truncation of the negative heterochromatin regulator Epe1 mediates antifungal resistanceDOI 10.1101/2021.12.20.473483Read

Epigenetic gene silencing by heterochromatin primes fungal resistanceSemantic proximity Read

Epigenetic gene silencing by heterochromatin primes fungal resistance.Semantic proximity Read

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistance.Semantic proximity Read

Heterochromatin epimutations impose mitochondrial dysfunction to confer antifungal resistanceSemantic proximity Read

The JmjC domain protein Epe1 prevents unregulated assembly and disassembly of heterochromatin.Semantic proximity Read

Chromatin-Mediated Regulation of Genome Plasticity in Human Fungal PathogensSemantic proximity Read

Epigenetic Regulation of Antifungal Drug ResistanceSemantic proximity Read

An H3K9 methylation-dependent protein interaction regulates the non-enzymatic functions of a putative histone demethylase.Semantic proximity Read

The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery.Semantic proximity Read

The 19S proteasome is directly involved in the regulation of heterochromatin spreading in fission yeast.Semantic proximity Read

Rapid epigenetic adaptation to uncontrolled heterochromatin spreading.Semantic proximity Read

Heterochromatin and RNAi act independently to ensure genome stability in Mucorales human fungal pathogensSemantic proximity Read