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Article

Genome-wide screen of genes required for caffeine tolerance in fission yeast.

PloS one - 12 Aug 2009

Calvo Isabel A, Gabrielli Natalia, Iglesias-Baena Iván, García-Santamarina Sarela, Hoe Kwang-Lae, Kim Dong Uk, Sansó Miriam, Zuin Alice, Pérez Pilar, Ayté José, Hidalgo Elena

Abstract excerpt

BACKGROUND: An excess of caffeine is cytotoxic to all eukaryotic cell types. We aim to study how cells become tolerant to a toxic dose of this drug, and the relationship between caffeine and oxidative stress pathways. METHODOLOGY/PRINCIPAL FINDINGS: We searched for Schizosaccharomyces pombe mutants with inhibited growth on caffeine-containing plates. We screened a collection of 2,700 haploid mutant cells, of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 19672306
DOI: 10.1371/journal.pone.0006619
PMCID: PMC2720375

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Source receipt: pubmed, retrieved 7 Sept 2026.

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