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Extrachromosomal circular DNAs in the differentiation of human bone marrow mesenchymal stem cells

18 Jul 2025

Abstract excerpt

BACKGROUND: Extrachromosomal circular DNA (eccDNA) plays a significant role in cancer development. However, our understanding of its role in normal cells is limited. This study aimed to explore the roles of eccDNA in the differentiation of human bone marrow mesenchymal stem cells (BMSCs). METHODS: Through circular DNA sequencing (Circle-seq) and computational analysis, we documented eccDNAs in human BMSCs and...

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PMID: 40682088
DOI: 10.1186/s13287-025-04516-x

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