Article

Cell-cycle dependent organization and dynamics of RNA Polymerase I in live human cells

2017-05-01

Abstract excerpt

RNA Polymerase I (Pol I) is responsible for over 60% of transcriptional output in human cells, yet basic questions concerning the spatial and temporal organization of the polymerase remain unanswered. Here we investigate how mammalian cells rely on Pol I organization throughout the cell cycle to balance different needs, from complete transcription shut down to massive increase in protein synthesis (and thus riboso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ae494f0f-0760-5d58-b224-2c7837c27c59
DOI: 10.1101/133082

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Cell-cycle dependent organization and dynamics of RNA Polymerase I in live human cellsDOI 10.1101/133082Read

Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblastsSemantic proximity Read

RNA polymerase II initiation factors show different dynamic behaviour upon induced transcription in live cellsSemantic proximity Read

Multi-timescale PTM architecture in human RNA polymerase IISemantic proximity Read

Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiationSemantic proximity Read

Cell size-dependent mRNA transcription drives proteome remodelingSemantic proximity Read

Nuclear Remodeling in Quiescent Cells: Conserved Mechanisms from Yeasts to MammalsSemantic proximity Read

Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast.Semantic proximity Read

Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing, chromatin, and exons.Semantic proximity Read

Dynamic transcription pre-initiation complex assembly governs initiation efficiencySemantic proximity Read

Zooming in on single active genes in living mammalian cells.Semantic proximity Read

Global landscape of replicative DNA polymerase usage in the human genomeSemantic proximity Read

High-resolution mapping of human RNA polymerase III reveals transcription termination as a rate-limiting stepSemantic proximity Read