Article
Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast.
BMC genomics - 26 Jan 2017
Young Conor P, Hillyer Cory, Hokamp Karsten, Fitzpatrick Darren J, Konstantinov Nikifor K, Welty Jacqueline S, Ness Scott A, Werner-Washburne Margaret, Fleming Alastair B, Osley Mary Ann
Abstract excerpt
BACKGROUND: Quiescent cells have a low level of gene activity compared to growing cells. Using a yeast model for cellular quiescence, we defined the genome-wide profiles of three species of histone methylation associated with active transcription between growing and quiescent cells, and correlated these profiles with the presence of RNA polymerase II and transcripts. RESULTS: Quiescent cells retained histone...
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