Article

Multi-timescale PTM architecture in human RNA polymerase II

2026-06-29

Abstract excerpt

<h4>Summary</h4> Human RNA Polymerase II (Pol II) is characterized by a dense layer of over 775 post-translational modifications (PTMs) that form a dynamic, rewritable regulatory architecture integrating large numbers of cellular signals to coordinate transcription initiation, elongation, termination, and co-transcriptional RNA processing. While genomic information has been extensively catalogued, the potential i...

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Literature Corpus work: 7734ac1b-a154-5aa3-8c57-24873d9aa13a
DOI: 10.64898/2026.06.27.734958

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