Article

Cell size-dependent mRNA transcription drives proteome remodeling

2025-10-31

Abstract excerpt

Increasing cell size drives proteomic changes that impact cell physiology. However, the molecular basis of size-dependent proteome remodeling has remained unclear. Here, we develop an inducible Cyclin D1 expression system in human cells to generate populations of proliferating cells spanning over a two-fold size range. We use this genetic system to make comprehensive genome-wide measurements of mRNA and protein co...

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Literature Corpus work: 910fae15-5e21-5352-8838-05b628bbd105
DOI: 10.1101/2025.10.30.685141

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