Article

Cell-cycle dynamics of nascent transcription and mature RNA accumulation are concordant in normal fibroblasts

2025-09-16

Abstract excerpt

<h4>ABSTRACT</h4> Cell-cycle dynamics of gene expression are fundamental to life, yet their origin remains unclear. A prevailing model, derived from cancer cells, posits that transcription occurs in one cell cycle phase, while mature RNA accumulates in subsequent phases, suggesting temporal segregation of transcriptional regulation and RNA abundance. Whether this paradigm applies to normal human cells is unclear....

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Literature Corpus work: be962cf0-4b24-5ab7-b6d6-cc8c470e4fbb
DOI: 10.1101/2025.09.12.675830

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