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Article

Nucleolar activity and CENP-C regulate CENP-A and CAL1 availability for centromere assembly in meiosis.

Development (Cambridge, England) - 15 Apr 2016

Kwenda Lucretia, Collins Caitriona M, Dattoli Anna A, Dunleavy Elaine M

Abstract excerpt

The centromere-specific histone CENP-A is the key epigenetic determinant of centromere identity. Whereas most histones are removed from mature sperm, CENP-A is retained to mark paternal centromeres. In Drosophila males we show that the centromere assembly factors CAL1 and CENP-C are required for meiotic chromosome segregation, CENP-A assembly and maintenance on sperm, as well as fertility. In meiosis, CENP-A...

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Identifiers

PMID: 27095496
DOI: 10.1242/dev.130625
PMCID: PMC4852514

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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