Article
An E3 ubiquitin ligase prevents ectopic localization of the centromeric histone H3 variant via the centromere targeting domain.
Molecular cell - 12 Nov 2010
Ranjitkar Prerana, Press Maximilian O, Yi Xianhua, Baker Richard, MacCoss Michael J, Biggins Sue
Abstract excerpt
Proper centromere function is critical to maintain genomic stability and to prevent aneuploidy, a hallmark of tumors and birth defects. A conserved feature of all eukaryotic centromeres is an essential histone H3 variant called CENP-A that requires a centromere targeting domain (CATD) for its localization. Although proteolysis prevents CENP-A from mislocalizing to euchromatin, regulatory factors have not been...
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