Article

Circadian disruption enhances HSF1 signaling and tumorigenesis in Kras-driven lung cancer

2022-01-31

Abstract excerpt

Disrupted circadian rhythmicity is a prominent feature of modern society and has been designated as a probable carcinogen by the World Health Organization. However, the biological mechanisms that connect circadian disruption and cancer risk remain largely undefined. We demonstrate that exposure to chronic circadian disruption (chronic jetlag, CJL) increases tumor burden in a mouse model of KRAS-driven lung cancer....

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Literature Corpus work: ade7d591-2ebe-5b3e-9b9b-59cd2214e3b2
DOI: 10.1101/2022.01.31.478213

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