Article

Widespread dysregulation of the circadian clock in human cancer

2017-04-25

Abstract excerpt

The mammalian circadian clock is a critical regulator of metabolism and cell division. Although multiple lines of evidence indicate that systemic disruption of the circadian clock can promote cancer, whether the clock is disrupted in primary human tumors is unknown. Here we used transcriptome data from mice to define a signature of the mammalian circadian clock based on the co-expression of 12 genes that form the...

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Identifiers and source

Literature Corpus work: 746a5a35-ddea-589b-bdbc-b2bc44ea8beb
DOI: 10.1101/130765

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