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Article

HSF1, a versatile factor in tumorogenesis.

Current molecular medicine - 1 Nov 2012

Calderwood S K

Abstract excerpt

HSF1 is an essential factor in the acute response to proteotoxic stress, in which it causes rapid transcription of heat shock protein (HSP) genes in order to permit survival of cells and restoration of global protein quality. In addition to this property however, HSF1 is chronically activated or overexpressed in a wide range of cancers and is essential for multiple pathways of malignant transformation. Studies in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22804234
DOI: 10.2174/156652412803306675
PMCID: PMC4075975

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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HSF1, a versatile factor in tumorogenesis.PMID 22804234Read ↗

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HSF1: Guardian of Proteostasis in CancerSemantic proximity Read ↗

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