Article

Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

2022-03-01

Abstract excerpt

<h4>ABSTRACT</h4> Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection following SCRD remain poorly characterised. To address this, we investigated the effects of acute sleep deprivation on the mouse lung transcriptome. Here we show t...

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Literature Corpus work: b122ac1c-3f7f-5d4d-b4d6-a43c6fedaca0
DOI: 10.1101/2022.02.28.482377

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