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Sleep and circadian rhythm disruption alters the lung transcriptome to predispose to viral infection

24 Dec 2022

Abstract excerpt

Sleep and circadian rhythm disruption (SCRD), as encountered during shift work, increases the risk of respiratory viral infection including SARS-CoV-2. However, the mechanism(s) underpinning higher rates of respiratory viral infection following SCRD remain poorly characterized. To address this, we investigated the effects of acute sleep deprivation on the mouse lung transcriptome. Here we show that sleep...

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PMID: 36590897
DOI: 10.1016/j.isci.2022.105877

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