Article
Circadian Rhythm Disruption Promotes Lung Tumorigenesis.
Cell metabolism - 9 Aug 2016
Papagiannakopoulos Thales, Bauer Matthew R, Davidson Shawn M, Heimann Megan, Subbaraj Lakshmipriya, Bhutkar Arjun, Bartlebaugh Jordan, Vander Heiden Matthew G, Jacks Tyler
Abstract excerpt
Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesti...
Topics
- Adenocarcinoma
- Adenocarcinoma of Lung
- Animals
- Carcinogenesis
- Cell Proliferation
- Cell Transformation, Neoplastic
- Cellular Reprogramming
- Circadian Rhythm
- Glucose
- Glutamine
- Humans
- Jet Lag Syndrome
- Lung
- Lung Neoplasms
- Mice, Inbred C57BL
- Mutation
- Period Circadian Proteins
- Proto-Oncogene Proteins c-myc