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Article

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis.

Cell - 21 Sept 2007

Dai Chengkai, Whitesell Luke, Rogers Arlin B, Lindquist Susan

Abstract excerpt

Heat shock factor 1 (HSF1) is the master regulator of the heat shock response in eukaryotes, a very highly conserved protective mechanism. HSF1 function increases survival under a great many pathophysiological conditions. How it might be involved in malignancy remains largely unexplored. We report that eliminating HSF1 protects mice from tumors induced by mutations of the RAS oncogene or a hot spot mutation in...

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Source

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Identifiers

PMID: 17889646
DOI: 10.1016/j.cell.2007.07.020
PMCID: PMC2586609

Genes

HSF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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