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Article

Genomic and TCR profiling data reveal the distinct molecular traits in epithelial ovarian cancer histotypes.

Oncogene - 1 May 2022

Zhu Shan, Zhang Chunliu, Cao Dongyan, Bai Jing, Yu Shuangni, Chen Jie, Wang Jing, Ren Tong, Yang Jiaxin, Yu Mei, Xiao Xiao, Gong Yuhua, Guan Yanfang, Li Peiling, Yue Ying, Yin Rutie, Wang Yongjun, An Ruifang, Lou Ge, Yuan Jianlin, Zhang Guonan, Xia Xuefeng, Yang Ling, Xiang Yang

Abstract excerpt

Epithelial ovarian cancer (EOC) is classified into five major histotypes: high-grade serous (HGSOC), low-grade serous (LGSOC), clear cell (CCOC), endometrioid (ENOC), and mucinous (MOC). However, the landscape of molecular and immunological alterations in these histotypes, especially LGSOC, CCOC, ENOC, and MOC, is largely uncharacterized. We collected 101 treatment-naive EOC patients. The resected tumor tissues...

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Identifiers

PMID: 35468938
DOI: 10.1038/s41388-022-02277-y

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