Article

Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

2024-03-20

Abstract excerpt

<h4>Summary</h4> To uncover the intricate, chemotherapy-induced spatiotemporal remodeling of the tumor microenvironment, we conducted integrative spatial and molecular characterization of 97 high-grade serous ovarian cancer (HGSC) samples collected before and after chemotherapy. Using single-cell and spatial analyses, we identify increasingly versatile immune cell states, which form spatiotemporally dynamic micro...

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Literature Corpus work: 7d4a7147-723f-57d0-88de-ad6e568a8f09
DOI: 10.1101/2024.03.19.585657

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