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High prevalence of somatic <i>PIK3CA</i> and <i>TP53</i> pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencing

2021-09-27

Abstract excerpt

The mammary gland undergoes hormonally stimulated cycles of proliferation, lactation and involution. We hypothesized that these factors increase the mutational burden in glandular tissue and may explain high cancer incidence rate in the general population and recurrent disease. Hence, we investigated the DNA sequence variants in the normal mammary gland, tumor and peripheral blood from 52 reportedly sporadic breas...

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Literature Corpus work
adca5790-0259-5fcc-9ddf-c3b66c3389af
DOI
10.1101/2021.09.27.21263863
Open publication

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High prevalence of somatic <i>PIK3CA</i> and <i>TP53</i> pathogenic variants in the normal mammary gland tissue of sporadic breast cancer patients revealed by duplex sequencingDOI 10.1101/2021.09.27.21263863
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