Article
Concurrent DNA Copy-Number Alterations and Mutations in Genes Related to Maintenance of Genome Stability in Uninvolved Mammary Glandular Tissue from Breast Cancer Patients.
Human mutation - 1 Nov 2015
Ronowicz Anna, Janaszak-Jasiecka Anna, Skokowski Jarosław, Madanecki Piotr, Bartoszewski Rafal, Bałut Magdalena, Seroczyńska Barbara, Kochan Kinga, Bogdan Adam, Butkus Małgorzata, Pęksa Rafał, Ratajska Magdalena, Kuźniacka Alina, Wasąg Bartosz, Gucwa Magdalena, Krzyżanowski Maciej, Jaśkiewicz Janusz, Jankowski Zbigniew, Forsberg Lars, Ochocka J Renata, Limon Janusz, Crowley Michael R, Buckley Patrick G, Messiaen Ludwine, Dumanski Jan P, Piotrowski Arkadiusz
Abstract excerpt
Somatic mosaicism for DNA copy-number alterations (SMC-CNAs) is defined as gain or loss of chromosomal segments in somatic cells within a single organism. As cells harboring SMC-CNAs can undergo clonal expansion, it has been proposed that SMC-CNAs may contribute to the predisposition of these cells to genetic disease including cancer. Herein, the gross genomic alterations (>500 kbp) were characterized in...
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