Article
Prevalence of germline TP53 variants among early-onset breast cancer patients from Polish population.
Breast cancer (Tokyo, Japan) - 1 Jan 2021
Rogoża-Janiszewska Emilia, Malińska Karolina, Górski Bohdan, Scott Rodney J, Cybulski Cezary, Kluźniak Wojciech, Lener Marcin, Jakubowska Anna, Gronwald Jacek, Huzarski Tomasz, Lubiński Jan, Dębniak Tadeusz
Abstract excerpt
BACKGROUND: The objective of this study was to determine spectrum and prevalence of germline mutations in TP53 gene among Polish women with early-onset breast cancer (BC), which has not been determined until now. METHODS: A cohort of 100 females with BC diagnosed ≤ 30 years of age and with a positive family history of cancer was used as a discovery cohort. 1880 women with BC ≤ 45 years old and a control group of...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Case-Control Studies
- Cohort Studies
- DNA Mutational Analysis
- Female
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Heterozygote