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Article

Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer.

Endocrine-related cancer - 1 Apr 2015

Ni Ying, Seballos Spencer, Ganapathi Shireen, Gurin Danielle, Fletcher Benjamin, Ngeow Joanne, Nagy Rebecca, Kloos Richard T, Ringel Matthew D, LaFramboise Thomas, Eng Charis

Abstract excerpt

Along with breast and endometrial cancers, thyroid cancer is a major component cancer in Cowden syndrome (CS). Germline variants in SDHB/C/D (SDHx) genes account for subsets of CS/CS-like cases, conferring a higher risk of breast and thyroid cancers over those with only germline PTEN mutations. To investigate whether SDHx alterations at both germline and somatic levels occur in apparently sporadic breast cancer...

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Source

Open in PubMed Open full text

Identifiers

PMID: 25694510
DOI: 10.1530/ERC-14-0537
PMCID: PMC4335266

Genes

SDHC
PTEN
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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