Article
The mutational landscape of the adult healthy parous and nulliparous human breast.
Nature communications - 6 Sept 2023
Cereser Biancastella, Yiu Angela, Tabassum Neha, Del Bel Belluz Lisa, Zagorac Sladjana, Ancheta Kenneth Russell Zapanta, Zhong Rongrong, Miere Cristian, Jeffries-Jones Alicia Rose, Moderau Nina, Werner Benjamin, Stebbing Justin
Abstract excerpt
The accumulation of somatic mutations in healthy human tissues has been extensively characterized, but the mutational landscape of the healthy breast is still poorly understood. Our analysis of whole-genome sequencing shows that in line with other healthy organs, the healthy breast during the reproduction years accumulates mutations with age, with the rate of accumulation in the epithelium of 15.24 ± 5...
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